Diabetes itself are stubborn disease, is also one causes other disease succeeding in the imperial civil service examinations sickness to plant. Diabetes complication mainly has a mind the blood vessel of brain complication, tooth disease, skin disease, the sexual desire to drop, the menstruation to be unusual. The Guangxi Nanning Tongji University Hospital adopts one new method - - use to have the force purification blood function hirudin, treats the heart blood vessel of brain complication, has made the tangible progress. Now, we treat diabetes take the hirudin fully as the examples, carries on the medicine analysis.

　　Diabetes are fully diabetes synthesize pathological change general names and so on foot ache which, skin deep ulcer, acromelic gangrene the factor causes, is one of diabetes chronic complications, also causes the diabetic patient amputation disabled primary cause.

　　Diabetes blood vessel pathological change and the nerve pathological change are cause the diabetes full complications's basic cause, diabetes patient, because the nerve pathological change often causes foot's sensation of pain vanishing or decreases, but easy to receive the flesh wound, the slight flesh wound can cause ulcer, the infection and the gangrene rapidly, so that can not but the amputation, the amputation rate reach as high as 40% finally.

　　Diabetes full pathogenesis

　　1 nerve pathological change sends the feeling barrier causes the diabetes full foundation

　　The body blood vessel's nervus autonomici pathological change causes the blood vessel movement to be weaken, the partial organization resistivity reduces, the small wound then causes the infection, because and the partial feeling barrier, the small pathological change cannot the immediate cure, cause the wound to expand rapidly. Meanwhile as a result of body feeling barrier, but also easy to cause to scald. The nerve pathological change may cause the foot small ischemic muscular atrophy, because the long muscle pulls without the antagonism pulls, forms the fingernail shape tip of toe [is specially third, fourth and five feet]. This kind causes zhi the bone to become the center of resistance which abnormally the full bottom carries a heavy load, because rubs, has the callus formation, extremely easy to have the infection and the penetrability ulcer, causes osteomyelitis the heavy proliferation to the nearby skeleton. Because felt deeply evanishment and the joint motor reflex barrier, causes the patient in the unconscious situation, some joint load was excessive, loses to has been many times redundant the wound the protection function, caused the joint and the facies articularis becomes very anomalous, easy to have the bone fracture, the joint dislocation and half dislocation, specially zhi foot joint.

　　2 lower limbs have the arteriosclerosis to cause the foot ischemia, urges the diabetes full occurrence

　　The lower limb has the arteriosclerosis to cause the foot ischemia, urges diabetes full occurrence lower limb occurrence. After arteriosclerosis, causes the foot ischemia, specially the tip of toe, in addition the minute vessel and the capillaries pathological change, cause the tip of toe blood pressure to drop to whole body blood pressure half or are lower. Patient Chang Yu sleeps soundly at night when gets out of bed because of the tip of toe ache, and must walk several steps can alleviate. In certain needs to increase the blood circulation rapidly in the situation (for example flesh wound, infection, underheating and overheated and so on) the blood stream cannot increase correspondingly, may cause the gangrene, especially take tip of toe as really.

　　3 infections cause the diabetes full blasting fuse

　　The nerve pathological change and the ischemia easy to cause the partial wound, following sends the serious infection. In the slight wound like full bottom's pressure sore, the toenail prunes excessively short, athlete's foot treatment not, when may cause following sends the infection. In the full base pressure load spot skin and the hypodermic textile fiber Fatty tissue may the accumulation, once the heel department had the infection, easy to all around to proliferate rapidly, the ligament wound may cause the infection proliferation, causes zhi the bone osteomyelitis. Has wet, to do and the mixing property gangrene according to the ischemia degree.

　　After diabetes foot sickness, the toe and the extremity will lose partial or the complete functions, finally can not but adopt the amputation the method to preserve the life.

　　Hirudin to diabetes full function

　　Clinical case Sun Yu Hua, male, 62 years old, Guangxi Zhuang Autonomous Region news publication board somewhere department head. The long-term