The hepatitis B “big three positive” (hepatitis B five 135 masculine genders) are refer to the liver disease patient blood test surface antigen, E the antigen and the core immune body examination assume the masculine gender. Generally, the hepatitis B big three positive infection are relatively strong, simultaneously evolves chronic hepatitis B the possibility quite to be also big. Hepatitis B major three positive present common features: The viral duplication is active, the infection is strong, the liver damage is serious, the symptom is obvious.

　　[disease cognition]- - by two fifty-fifty, knows “the hepatitis B in a big way three positive”

　　The hepatitis B “two fifty-fifty”, are the present domestic hospital most commonly used hepatitis B virus (HBV) infection examination blood serum designated objects. The hepatitis B virus immunology marks the altogether 3 pairs, namely surface antigen (HBsAg) and surface antibody (anti-HBs either HBsAb), e antigen (HBeAg) and e immune body (anti-HBe or HBeAb), core antigen (HBcAg) and core immune body (anti-HBc or HBcAb). As a result of core antigen blood Yi Cedao, the reagent box does not go through a strategic pass at present, therefore also remains two fifty-fifty antigen immune bodies, this was the people often says “the hepatitis B two fifty-fifty” the inspection, or called “the hepatitis B five items” the inspection.

　　At the hepatitis B “two fifty-fifty” in the inspection, surface antigen (HBsAg), e immune body (HBeAb) and the core Hangzhou body (HBcAb) demonstration masculine gender, is “big three positive”. The big three positive viral duplication is active, the infection is strong, the liver damage is serious, the symptom is obvious, is the hepatitis B major three positive present common features.

　　“hepatitis B big three positive” three kind of courses, decision treatment strategy

　　The hepatitis B big three positive (hepatitis B five 135 masculine genders) are only reflected that in the human body carries viral the condition, cannot reflect the liver function normally or not, thus cannot use for to judge the condition the weight. Must want to understand the liver function condition, should better makes further comprehensive liver function appraisal, like routine blood test, liver function (ALT, AST, BIL, TP/A), HBVDNA quota, ultrasound and so on, then basis check result judgment course.

　　1st, the liver function normal, not clinical symptoms, each inspection have not seen the liver obvious damage. This kind of patient should the dynamic observation, every 3-6 months carry on a time HBV serology and the liver function biochemistry target and the ultrasound examination, should avoid in the life drinking wine overtiredly with.

　　2nd, the liver function is not normal, the HBVDNA masculine gender, has the clinical symptoms, prompts the chronic hepatitis active stage. This kind of patient must accept to the hospital guarantees the liver or the anti-viral treatment.

　　3rd, the liver function is normal, not obvious symptom, other check result (ultrasound and so on) prompts the liver to have the harm. This kind of patient must make the liver puncture Living specimen Organization to inspect, like the liver organization pathological change is slight, processing situation with 1; If the pathology change conforms to the chronic activity hepatitis, then processing situation with 2.

　　[goes see a doctor instruction]- - “hepatitis B big three positive” different period not Tongzhi

　　1st, chronic mild hepatitis B (the past called chronic to procrastinate hepatitis B) the patient to display in a big way to three positive

　　Treatment goal: Liver function long-term stability is normal, hepatitis B virus duplication target cloudy extension.

　　2nd, chronic heavy, hepatitis B (the past called chronic activity hepatitis B) to display in a big way to three positive

　　Treatment goal: The liver function tends to be balanced gradually, the hepatitis B virus duplication target is cloudy gradually the extension.

　　3rd, liver cirrhosis patient display in a big way to three positive, commutation time or repose period liver cirrhosis patient (ultrasound prompt liver cirrhosis, but liver function inspection basic normal).

　　Treatment goal: The hepatitis B virus duplication target cloudy extension, the liver fibrosis degree reduces.

　　4th, loses the commutation time or the active stage liver cirrhosis patient display in a big way to three positive.

　　Treatment goal: Controls and prevents the complication (ascites, hydrothorax, hemorrhage, infection and so on), to restore the liver function, the viral duplication target cloudy extension.