Similarly infected the hepatitis B virus, some people then the self-recovery, some people actually will induce why the hepatitis B even to develop liver cirrhosis soon? This puzzle medical arena many year question marks, already by part success explanation. Reporter learned the other day: Fudan University immunity biology research institute's expert, has promulgated the hepatitis B virus infection new mechanism for the first time in the whole world, TRIM22 which the human body exists originally the member, just likes the hepatitis B virus “the controlling switch”, activates it then to be able to suppress the viral duplication, to prevent the hepatitis B to produce. The research results have published in the international well-known publication "Liver complaint Study Magazine", industry in the expert believed that the recent discovery will boost hepatitis B medicine screening and so on a series of clinical researches.

　　At present our country hepatitis B virus carrier approximately has 130,000,000 people, accounts for the total population about 1/10, the hepatitis B virus infection has become the significant public health question. What is astounding, in hepatitis B virus infected person, two kind of entirely different disease trend of development: After the partial infected people pass through the short course of infection, meets spontaneously the healing; The partial patients actually continue to carry the virus, but also some 25% carrier will develop the chronic hepatitis B, liver cirrhosis even liver cancer. In recent years, the global numerous scientists in view of the hepatitis B virus this “the strange behavior” the development research, actually could not find the reason to be.

　　Before more than four years, the team which leads by Fudan University immunity biology research institute Professor Xiong Sidong, begins to seek for the hepatitis B virus infection the mechanism. They first vision focusing in a famous member TRIM5α on. Xiong Sidong introduced that although this member to suppressed the AIDS virus the duplication crucial role, the hepatitis B virus and HIV is not the identical kind of virus, but both duplication behavior ten phase splitting elephant. By reason of the intuition, the research team has spent more than one year time, after innumerable experimental study TRIM5α, but the result actually quite makes one feel disappointed: This molecular and the hepatitis B virus duplication does not relate.

　　The experts therefore have not been discouraged: TRIM the member “the family” also some 70 “brothers can the member”, have to the hepatitis B virus produces the function member? Holds the manner which tries to look, the research team is experimenting one by one 70 member. “the time does not lose the person with high aspirations”, has locked the TRIM22 member finally! Regarding the hepatitis B virus infected person, once in vivo TRIM22 member is stimulated rapidly, the carrier then may induce the corresponding immune response, suppresses the viral duplication, eliminates in vivo the hepatitis B virus. This member, in the certain extent played the control hepatitis B virus “the switch” role.

　　Has found “the switch”, will bring the significant change for the hepatitis B clinical care and the research. The expert explained that recent discovery's member possibly develops for the hepatitis B virus infected person clinical prognosis, disease advancement important monitor target, assists doctor by this to draw up the therapeutic schedule. The medical arena always believed that the antivirotic medicine is most effective to the hepatitis B virus; The recent discovery actually promulgated activated TRIM22 the member to be possible to suppress the viral duplication, this will impel the hepatitis B to treat in the domain immunity adjustment class medicine screening. In addition, has many traditional Chinese medicines to confirm that to suppresses the hepatitis B virus to be effective, actually suffers from lacks the theory basis, the recent discovery is very possible to promulgate the Chinese medicine in the hepatitis B domain action mechanism.

　　The TRIM22 member “presents” is the first step. Then, Xiong Sidong will conduct the dissect with his research team to it in the hepatitis B virus infection's concrete function, made every effort to find activates the TRIM22 member the secret, brought the healing hope for the counted by the 100 million hepatitis B virus infected person.